Not so good friend of mine showed me a couple pictures of a Virginia deer that was supposedly hit with a 50BMG with some kind of handload that he didn't know the details of. He has family that works in firearms research for the government, or so he tells me.
Anyway, on one side the deer looked just fine with a small hole and really no blood. On the other side, the entire far side of the deer was pretty much gone for about 15", the near side ribs were torn out, some were gone, some were pointing not where they should be. Honestly, I didn't believe that it was a 50 BMG. Before I saw those pictures, I would have been willing to bet money that any 50 BMG would have sailed right through leaving a small hole on each side. The 50 doesn't have enough velocity to do the strange things that the fast 22s and 6mms do but what do I know. The only game I've ever taken larger than 50 lbs has been with a .270.