I have a CVA Hawken .50, it's a 1:66.
The cheap CVA mountain stalker start up kits come in 1:48 and 1:32 in .50 cal, you just need to read the package to know which it is.
My 1:48 CVA is sighted at 50, but was VERY particular about powder load. It likes 80FFFg; with that it'll hold all 5 shots in an inch. Any more or less and it opens up in a HURRY.
The Hawken is the one that I'll string out to 100 yards with a round ball. I have it sighted at 100 with 110 grains of FFFg. It's not quite as particular about it's powder load, but the accuracy does fall off over 110 and under 90.
It's a matter of knowing your gun, knowing your load, and having confidence in your ability to make the shot. Making consistent 100 yard shots also takes a good amount of bench time. I burned through at least a pound of powder off the bench trying different loads until I got the Hawken sighted in and shooting consistently enough to where i had absolute confidence in the rifle at 100.
It's just like developing a handload in a cartridge rifle; you have to find exactly what the rifle likes, but with black powder the lower speeds leaves a lot less room for error on the part of the shooter.
And yes, sight in with your exact hunting load. you can practice lighter, but little changes in powder make large changes in trajectory.