I never gave the material much thought, until, like several others, I bought a Glock 22. My gun buying has never been the same.
Besides the Glock 22, I own a Walther PPS 9MM ( GREAT carry pistol and very Glock like), a Kahr CW .380 ACP and a Ruger SR22P. All polymer, all very light and easy to carry and all are extremely reliable, especially the Glock and the Walther.
While I love the look of blued steel and and nice grips, my Ruger Blackhawks have custom grips, the one pistol I would grab would be the Glock.