I went through this situation with a bailiff/retired detective/friend/shooting buddy who has wrist problems. He prefers big bore (.45), but has been limited due to his wrist problems. After a couple of shots from his .45, he can (and has) actually lost all sense of feeling in his fingers. Not a good idea for a gunfight.
Anyways, he still has good hand strength, and had no problem working a revolver. So, we ended up getting him a 4" Smith 66 revolver with Hogue rubber grips, and loading up with +p 158 grn LSWHP loads (the old FBI load). Recoil is not problematic, ammo has a proven record of ending hostilities, and overpenetration is a minimal concern.
If his wrist can handle the weight, look into a Smith 686+, and he should be well protected.