With my single stage press, I can flip on the lights in my reloading room and flip them off an hour later and have 100 rounds loaded starting with resized and clean cases. Not hard but lots of case handling and handle pulling.
I bought my progressives as new toys to play with and eliminate some of the case handling. Volume wasn't a main reason.
I can load 500-600 rounds in a 3 hour evening, lights on to lights off. About half that time is actually stroking the handle. The rest of the time is setting up, filling primer trays, storing ammunition away, cleaning up and so forth.
I rarely leave my press set up for one cartridge because I rarely load the same cartridges two sessions in a row. So, leave the press "stripped" at the end of a session so that it ready to take on the next cartridge gear.
If you leave the press set up for one cartridge, there will be less set up time.
I have a Hornady L-N-L and two Dillon SDBs (dedicated for 9x19 and 45 ACP). I prefer auto-index so the Dillon 550b was a non-starter for me.