I don't really have anything to add that hasn't already been said.
@Obturation said it all, really.
The only guns I have ever had any leading issues with have been revolvers, owing to sizing differences between chamber throats and bore diameter (nature of the beast with revolvers, unfortunately). I've personally never had leading problems in a rifle or automatic pistol, as long as the bullet is not undersized.
Bullet size is definitely the biggest key. Next priority is probably to match bullet hardness to your loads. To keep it simple, softer loads calls for softer lead, and stronger loads call for stronger lead. If the bullet is too hard, it will fail to obturate (i.e. to have the base of the bullet expand when the gas pushes it), which can cause poor contact with the rifling, thereby allowing hot gases to escape past the bullet, thereby soldering lead from the sides of the bullet to the rifling as the bullet passes.
General rule is that you want a lead bullet to be .001-.002 larger than your bore diameter. Most likely, your rifle's bore diameter will be in the neighborhood of.4575 and .458, which means a .459 bullet will be ideal, and is what you'll find most commonly sold. If your bore happens to be a little bit wider, than a .460 bullet may be more appropriate.
My experience with .45-70 and lead echo's what
@Obturation shared. I've never experienced leading problem with any of the .45-70's I've had, pretty much regardless of what bullets I've used. I've pretty much only ever loaded 405 gr and 500 gr RNFP of various hardnesses, using anything from Trail Boss to moderate loads with 4198, and everything has worked great.
Good luck! Once you go lead, you will likely see no reason to go back.