With larger flake powders like Unique and Promo, I get .2 - .4+ gr variance charge-to-charge but even with the greater variance, loads are mostly still accurate.
Flattened and coated ball powders like WST, W231/HP-38, WSF, AutoComp, etc. meter very consistently in the Pro Auto Disk with about 60% of the drops right on and the rest varying by less than .1 gr.