I have a PPM and it works, mostly, with the various pistol powders I've tried. If you love really fine ball powders, it may not be a great choice. About the finest powder that runs smoothly is 4227. Accurate #5 and #9 (the only AA powders I've tried) both start to get sticky and sift a little out of the side of the drum (cone, whatever you want to call it) but they are not too bad to use. You just have to keep a firm grip on the lever. I have a pound of H110 and RAPIDLY decided to hand-weigh every charge: it bound up the drum nastily. (Luckily, I use it only for Redhawk-only .44 Magnum +P rounds, which I plan to shoot VERY sparingly since they are needlessly dramatic and probably muck up the primer pockets.) Unique feels a bit crunchy, but HP-38 is smoother, so I guess flake size matters.
Precision with 4227 is excellent. If a reading varies even a tenth of a grain, it's usually because my scale has drifted and needs to be re-zeroed. OTOH, Unique and IIRC Blue Dot genuinely vary +/- 0.1 grain, but rarely more than that. I think Longshot, Trail Boss and HP-38 are more consistent than Unique, but not as "Perfect" as 4227. With that powder, it lives up to its name.