What is the double action trigger pull weight on the model 325? The double action weight allows us to make a general estimation of the mainspring strength. And since a lack of mainspring tension is the most frequent cause of misfires, getting an estimate of the mainspring strength is very helpful for understanding this problem.
Also, what is the history of this revolver? Has it had trigger work? Did you buy it new? How many rounds have you fired through it? Did this problem suddenly arise?
The suggestion from Earplug to use a small primer cup as a shim on the end of the strain screw is a good one. If the mainspring tension is not quite enough, then shimming the strain screw often resolves the issue.
All of this, and much more, is described in the article I referenced above. I realize the article is quite long, but sometimes these problems are tricky, and there is a lot of info to cover.