When my Mini-30 was in it's factory original state it was very picky about bullets and powder. It loved (still does) Sierra 125gr .308 Pro Hunter bullets. It hated Nosler Ballistic Tips or any other Boat Tail bullet for that matter. If it wasn't a flat based bullet it wasn't going to shoot. I had OK results with Hornady 110 and 130gr Sp. It shot very well with Hornady 110gr V-Max.
For powders, it shot it's best with AA 2230. H 322, AA 2015 and H4198 were also very good. It never produced anything but mediocre groups with AA 1680. R-7 worked very well with some bullets and not so good with others. Like I said this rifle was very picky.
I also found that my Mini hated, just hated Winchester Brass(still does). Remington brass worked very well, but my Mini really liked the K & P (Lapua) brass my local guy used to sell for $18/100.
Seating depth, Primers and the amount of Crimp I applied all affected accuracy, but not nearly as much as my choice of bullets and powder.
If I were to start over from scratch with a new Mini-30 I would start with the following.
Lapua, K&P, IMI or Remington Brass
Primer pockets Uniformed and Flash holes deburred.
Fed 210m or CCI Br2 Primers in Large rifle case, Rem 7 1/2 in small rifle case
110gr Bullet Hornady V-Max
125gr Bullet Sierra .308 Pro Hunter
Powder Choice in order:
H4198
H 322
AA 2015
AA 1680
R-7