I moly coat basically every one of my rifle chamberings.
From .223 to jacketed .45-70. On my really hot numbers, like .220 Swift, 6.5-06, and 6.5-300 Weatherby, the difference is well worth the extra effort, especially with respect to copper fouling and accuracy over time. Lots of powder in big cases will chew up a barrel throat in short order, regardless of moly or any other embedded lube. Cleanup is easier, and, for my purposes at least, accuracy is maintained over a longer portion of the barrel's life. I use Nalgene centrifuge cones, or small plastic aspirin bottles, to moly coat about 20 or so bullets in my vibratory tumbler. Then I use a dedicated corncob media sifter to separate the bullets from the moly powder. I save the moly powder and use it again and again, as long as I use clean bullets to begin with. Depending on how industrious I feel, I go the extra step and wax the bullets before seating them in their respective cases.