Mossy Rifled Bbls...
are awesome!
Mata 777--I just concluded working 2 weekends and W-T-F of last week @ my gun club, on the 50-yd range, helping people sight in and practice with their shotguns and slugs.
We had a plywood "running deer"--which mostly just teaches people to not shoot @ a running deer--but they could shoot @ Plywood Bambi standing still and we could coach them, or we had targets @ 70 yd or for people with REAL problems, 20 yds.
So I'm currently VERY experienced with a variety of shotgun bbls, rifled and non, and a variety of shotgun slugs, the fancy Brenneke or Rottweils, or common Winchester lead pumpkins, and several brands of sabots. One shooter even brought Remington paper-shell slugs, would you believe! (How long has it been since those were made?)
Very experienced, yes indeed--TOO DARN experienced in one case--shot a slug gun for one customer to see if the problem was the gun or the shooter, and got kissed soundly in the eyebrow w/his 'scope. (Short stock, long 'scope, short eye relief, my long arms--You do the math.) BTW, the gun shot fine; shooter needed more practice.
For your Mossy 500 Rifled w/scope, you will probably want saboted bullets, not slugs. The Hornady sabots seem to work consistently the best with most rifled shotgun bbls. I know they are pricey--you can work some overtime and buy a couple boxes of Hornady sabots, but you can't buy a down deer; you have to shoot it yourself.
I have a Mossy 500 myself; like the model very much. (Mine is my goose gun.)
Now, as to sighting, you can roughly sight it with about 3 shots @ 25yd, however as Moo JPG 2 pointed out, you need to practice with it @ the range at which you expect to be dealing with Mr. Bambi. That means burning up a couple of boxes, at least, of those expen$ive darn slugs.
If the best range you can get is 50 yd, set the POI abt. 3" above the POA, and you should be lethal to 100 yd and beyond. But PRACTICE!!
Oh, well, if you were going to Africa to hunt, you'd be practicing with .416 Rigbys or .375 H&H's, at $3 or $4 per boom.