The old standby is Unique, and you can see from the number of posters recommending it, it is a good choice. The standard load is a 250 to 255 lead with 8.5 to 9.0 grains. That shoots to point of impact in all my fixed sight 45 LC revolvers.
I will give an honorable mention to W231, and I have a keg of AA #5, so I developed loads with that. It is a ball powder, the little powder balls clog up the powder bar on my Dillion 550. Other than that, it shoots well.
While Bullseye will shoot well, I would stay away from it, and Titegroup, as it is real easy to double charge Bullseye/Titegroup in this case. I tried Universal and it did not cluster as well as Unique. I am not impressed with it.
Check the throat diameters of your pistol. If they are larger, say 0.454 and up, your pistol will never shoot well with 0.452 cast lead bullets. It will shoot acceptably well with 0.452 JHP. Since I found commercial cast 0.454 bullets, that is what have been using in all my 45 LC pistols. I have included data which shows you cut Unique down to 8.0 grains, it still shoots well. Something else, this pistol has 0.452 cylinder chambers and yet 0.454 lead bullets make little to no difference in velocity, or in point of impact. Which is good.
Code:
M625-9 Mountain Gun 4" Barrel
250 JHP 8.5 grs Unique thrown, W-W cases, WLP primers
18-Mar-07 T = 55 °F V, accurate
Ave Vel = 830
Std Dev = 30
ES= 103.5
High= 893.4
Low= 789.8
Number Shots= 12
255 LSWC (.452") 8.0 grs Unique thrown, lot 6/21/1993Starline cases, WLP primers
25-Mar-07 T = 80 °F accurate
Ave Vel = 800
Std Dev = 30
ES 99.02
High 847.2
Low 748.1
Number Shots 11
250 LRN (.452") Valiant 8.0 grs Unique lot 6/21/1993 thrown, R-P cases, WLP primers
25-Mar 07 T = 80°F accurate
Ave Vel = 814
Std Dev = 24
ES 72.81
High 847
Low 774.2
Number Shots 11
250 LRN (.454") Valiant 8.5 grs Unique thrown lot 5471, 4/3/06, R-P cases, WLP primers
25-Mar-07 T = 80 °F accurate
Ave Vel = 891
Std Dev = 17
ES 61.31
High 921.1
Low 859.8
Number Shots 27
255 LSWC (.452") 8.0 grs Unique lot 6/21/1993 mixed cases WLP (nickel)
23-Sep-07 T = 82 °F
Ave Vel = 802.5
Std Dev = 31.03
ES = 123.5
High = 867.2
Low = 743.6
N = 12
250 LSWC (.452") 10.5 grs AA#5 lot 12599 mixed cases WLP (nickel)
23-Sep-07 T = 82 °F
Ave Vel = 875.1
Std Dev = 19.36
ES = 62.64
High = 905.7
Low = 843
N = 12
250 LSWC (.452") 10.5 grs AA#5 lot 12599 mixed cases Wolf NCLP
23-Sep-07 T = 82 °F
Ave Vel = 826.2
Std Dev = 20.14
ES = 63.38
High = 862.1
Low = 798.7
N = 12
View attachment 1080637