I've had a couple of .22-250s in the past and shot crows, pasture poodles, foxes, coyotes, and deer with them. Loved the cartridge, but didn't like handloading for it, since cases stretch more than any other cartridge I've loaded for. That's due to the amount of body taper.
I thought often about having it re-chambered for .22-250 Improved, but my rifles shot so well, I didn't wanted to screw them up. Both of my rifles shot sub-1/2 MOA and won many turkey shoots by 'closest to dead center' shots at 100 yards! In hindsight, the "Improved" version may have been the way to go.
I stopped using the .22-250 and converted my last one to .243 Win because I "probably" killed the last woodchuck in Maine. Not really, but we stopped hunting them. The .243 is much more forgiving in the wind and a better killer for larger varmints like Eastern coyotes and a better deer cartridge for grand-kids, of which four have used it with success.