are you looking for more mild loads? or more speed? i have used blue dot, h110 1680 and 300-mp in mine, all work, and plenty others do as well, just depends on what you are after. H110 is a pretty terrific powder for the 500 mag. I started using 300-mp when things were scarce and all you could find on the shelves were brand new stuff no one knew anything about and I assume afraid to try. I bought a bunch of it then and it has done everything H110 does.