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Well, I was willing to experiment, too. Here's the results I got:
I went to the safe and pulled out a CZ82 (same as the 83 but in 8x18)
It would require a vise or clamp, the slide requires full retraction to remove.
After that it would be easy, though. Bonus points to the 82 for:
- being in 9x18 instead of .380
- finish is crappy anyway, so you won't feel bad about marring it in a vise
- runs dirty jsut fine
- is cheaper for the gun AND for ammo if you order online
I kept looking, with guns easy to field strip in mind:
Yugo Tok and 1911 types - not without careful planning and tools.
Walther P.1 (or P.38/P.4/P.5) - maybe ... you need the slide locked open, then you flip a lever, then the slide goes off the front with some fiddling. I'm not sure I could get it on one-handed without support / clamping though, there are some points where you need stuff pushed up/down to clear the slide/frame.
CZ52 - this was promising, I checked it clear and popped off the slide with my weak hand ... and then I remembered that the barrel is locked into the slide requiring a punch to get it in/out (there's a hole on the bottom, no hammering involved) ... sadly, I think that removing the barrel from the slide would be a deal-breaker.
Kel-Tec P32/P3at/P11/PF9 family ... you have to remove a pin from the frame to get the slide off ... it might be possible with a clamp or weight to hold the gun down as the pin was pulled, getting everything back together might need some fiddling but I think it could be done. They're cheap but require cleaning, and are on the low end of the capacity spread.
Walther PPS - Clear the gun, pull the trigger (or remove the silly backstrap disabling device), pop the lever, and the slide falls off the front. The barrel and recoil spring come out one-handed, the mag release is friendly to either hand, but the mags are low-capacity, and I don't know how a one-handed man does a reload, but I think capacity might be a desirable feature. This was the easiest strip and re-assemble I have, though. I did it all left-handed.
Springfield XD - requires slide all the way back, you would need an empty magazine. We just pulled it off, there was some fumbling and I have a scratch in my wood desk (OK, I already had LOTS of scratches, no big deal) ... You get a major capacity upgrade and the XD will run dirty happily. It is the second-easiest strip, but I think the other features might push it to the top of the list.
... ... So, of what I have handy, I think the XD is the winner based on experimentation
You'll need a sturdy table edge to shove the slide back (it has a nice blocky rear sight)
You'll need an empty magazine to activate the slide latch during take-down and re-assembly
Loading mags is easy one-handed, plus mags are large to minimize reloading ... loading is easy to start with, a mag loader is in the box that will help for the last rounds
It runs fine dirty, so you won't have to clean it too often in the first place
The frame and slide can be cleaned with CLP spray and compressed air, plus a toothbrush for the feed ramp / rails, the barrel can be shoved down* on a cleaning rod / jag or rod & brush mounted to a workbench
It has an OK trigger and is plenty easy to run one-handed (I do weak-hand drills with it frequently)
Ambi mag release is easily activated with the middle finger of the firing hand
It eats anything, you can do a minimum of reliability testing
Not too expensive (hint, get the "essentials" pack without the junky holster/mag carrier)
In fact, the only thing I can think of that you'd need two hands for would be cleaning out the striker assembly ... and 1) I've never found anything in there anyway, plus 2) I'm sure it could be done, start in a large plastic bag because stuff is going to go flying if you don't have a "catch" hand.
* hey, I just had an idea, why not drill a hole in your workbench for mounting the cleaning rods to? No-handle rods, in this case. Then push the barrel down the rod ... that's actually how I do most of my handgun barrel cleaning, it might work best for one-hand operation because you set up the jag/rod/patch, then get the barrel, slide it over, and as you lift the barrel off you remove the patch
... tell me I'm an idiot if this is a bad idea, but I'm thinking about putting a hole on my bench just for laziness purposes