Deer Cartridges...
I killed 20 something with a Winchester 670 in .243, great rifle and cartridge. They were all one-shot kills, until 1990 something. Had a couple run on me that I had to track due to bullet failure...cheap ammo, thin skins...blew up and did not fully penetrate. I lost my faith in Walmart box ammo due to that.
My brother talked me into a .270 Winchester and the 130 grs never failed after that. That is my go-to rifle these days.
I have taken some of my other rifles and killed deer, notably my 7 x57 Mauser...it is a real sweetheart. Some with a .308 and also .30-06, both Model 70's (I Love them).
All the cartridges mentioned are great and more than adequate for deer, glad I don't have to choose just one. But if all you have is one gun in .243 to .30-06 you can't go wrong...as someone else said, practice with it til you are the expert.