Howdy
I agree. A heavier bullet causes more muzzle flip because there is more recoil, moving the point of impact up. I have two Remmies that I shoot with Black Powder cartridges with R&D conversion cylinders. Both are extremely accurate, probably my most accurate 45 Colt revolvers. I have always felt that this is because the chambers on these R&D cylinders are tighter than any of my other 45 Colt revolvers.
May I suggest that you slug your barrels, to find out what the groove diameter is you are dealing with? Since WWII, standard groove diameter for 45 Colt has been the same as 45 ACP, .451. That is why .452 bullets exist, they are .001 oversize for a .451 barrel.
My old EuroArms Remmie that I bought in 1968 has a very tight barrel, only .449, rather than .451. But it shoots fine with pure lead, .452 bullets, either 250 Grain pure lead Big Lube PRS bullets, or 200 grain J/P-200 Big Lube 200 grain bullets.
If you slug your barrel you may learn something about what diameter bullets it is looking for. Generally speaking, your chamber throats should be the same diameter as your rifling groove diameter, or maybe .001 or .002 larger. If that is the case, using bullets .001 over rifling groove diameter should serve you well.