Your pistol is a very early pistol and there are a couple of things to keep in mind for it. Perhaps the first is to understand that these early firearms were typically made from plain carbon steels, and often unheated carbon steels. It is not unusual to find cylinders, frames, barrels that are dead soft. While good condition revolvers are safe with period pressure loads, you should not attempt in any way to use hot loads in the things. Modern revolvers made of modern materials, even if they are replicas of these period pieces, will have a 25% to 50% higher yield strength just due to modern alloy steels.
Attempting to load hot rounds will beat these older revolvers up.
The period load for a M1909 Colt New Service was a 250-255 grain bullet at 755 fps in a five inch barrel. That is my recollection of data from Hatcher’s Textbook of Revolvers.
I have not found a better powder in the 45LC than Unique. I have tried a couple of others and Unique shoots best.
My data below, you might want to start with 8.0 grains Unique with a 250/255 Lead bullet. The 8.5 grain load is an excellent load, but I would consider it a max in period pistols.
The Bullseye load is right at period velocities.
Another thing, in older WW1 era 45 revolvers, I got leading with .452” lead bullets. You should seek to find .454” lead. I can measure chamber mouths, yours ought to be .455 or larger, and it is my belief that period barrels are .454” but I have not tried to slug one.
5" M25-7
255 LRN (.452") 8.5 grain Unique thrown R-P cases WLP (nickle) primers
26-May-97 T ≈ 75-80 ° F
Ave Vel = 869
Std Dev = 10
ES = 31
Low = 858
High = 889
N = 6
255 LRN (.452") 6.3 grs Bullseye thrown R-P cases WLP (nickle) primers
26-May-97 T ≈ 75-80 ° F
Ave Vel = 776
Std Dev = 11
ES = 28
Low = 765
High = 793
N = 6