Generally speaking, the larger the bore size, the larger the grandual size (or kernel size - aka single piece of powder). I suggest comparing loads of 2FG GOEX vs 1FG GOEX black powders. Remember too, that the coarser the black powder, the more fouling it produces than the finer grade of black powder. Typically, 2FG will burn faster than 1FG, thus creating pressure faster (and reducing fouling) , just like 3FG vs 2FG.
I am only comparing real black powder grades instead of black powder and black powder substitute. Because the finer grade powder produces pressure faster, the less one needs in the load. If using 125 grains of 1FG, probably 110 grains of 2FG will deliver the same "horsepower".
There are plenty of sources online for 10 gauge muzzleloading loads. In the 2016 Dixie Gun Works catalog, the recommended load for their Pedersoli 10 gauge double is 85 grains (3 drams) of 2FG with 1-1/4 oz of shot and the appropriate wads in between. But factories habitually err on the conservative side to stay away from future lawsuits. I have seen older publications books from the '70's and '80's recommending 2FG loads at 4 drams (27.5 gr X 4 dr = 110 gr measured) & 4-1/2 drams (124 gr [rounded off]).That was probably before the lawsuits started showing up in the court system.
In my custom-made 12 gauge flint double that I had, I got better patterns by decreasing the powder load about a 1/4 dram (about 7 grains). So, instead of 3 drams of 2FG, I used 2-3/4 drams.
If you mosey over to the Muzzleloading Forum at:
http://www.muzzleloadingforum.com/fusionbb/showtopic.php?tid/307597/post/new/#NEW
"Feltwad" (in England) discusses the 10 gauge duck gun and shows folks his collection of about a dozen originals. You will get a lot of assistance on that forum if you post your inquiry there, to augment the advice of the folks here .
If the above link and reference to another website violates the "house rules", administrator can slap my hand and delete the above paragraph.
Its hard to remember "house rules" on a dozen different sites.
Hope this helps.