If you are the kind of guy that likes to tinker, modify, reconfigure, etc, then the 10/22 is the 22 for you.
OTH, if you want a rifle that is
generally going to be more accurate out of the box, then the market opens up quite a bit. Honestly, there are too many good choices to list, IMO. Post #38 does make a great suggestion.
One bolt action 22 that I've not seen mentioned yet are the Soviet made CM2 target rifles. The rifles have an excellent reputation for accuracy, and last time I checked, CDNN had them for $299. Adjustable Diopter sights, fully adjustable trigger. Although at 26", they are a bit large for a 22. And it is a single shot, which may or may not be a deal breaker.
Personally, I love my CZ-452 Trainer and my Marlin/Glenfield Model 60. If you are going to get a CZ-452, IMO, I'd get a model equipped with iron sights like the Lux or Trainer, as they are quite excellent IMO. The rear sight looks like it came right off a Mauser K98, with different increments of course.
The Trainer is a decent value too. It is the same gun as the Lux with a less expensive beech stock, vs walnut. IMO, the beech looks nearly as nice as the walnut. I paid about $280 for mine a year ago, NIB. The mauser-style action is stiff at first, but after working the bolt a few hundred times it begins to smoothen out nicely. The stock trigger is respectable, but can be greatly improved with the $14 Eric Brooks trigger kit. And the stock fits me perfectly.
If you want a great value, IMO, hold out for a
USED Marlin Model 60. They are quite plentiful, as more Marlin Model 60s have been sold than any other 22 rifle. If you don't like tube fed guns, I believe the Model 75 is the same gun with a magazine. I actually prefer the feed tube, as there is no magazine to loose/keep up with. And it is very easy to load, to me anyway.
You may have seen my other thread, but I just picked up my Marlin Model 60 for $65 before tax from a local Pawn Shop. This particular Marlin/Glenfield was made in 1980, has a 22" barrel and holds 18 rounds in the tube. And thus far, it has proven to be very accurate. Not quite as accurate as my CZ, but not far behind.
Pretty awesome for $65, if you ask me. My Marlin/Glenfield is pictured below, followed by another I got from the same Pawn Shop for my dad for Father's Day. It is equipped with a cheap Tasco 4 x 15 scope, and cost $75 out the door.
Hard to beat two Marlin Model 60s for $140!