Mav,
You do the best you can with what you've got.
You try for a decent bullet & you try to hit your threat.
My primary points were marginal caliber, no magic .380 bullet, no FMJ, over concern with inches of penetration, extreme uncertainty & variability in actual use, and can't count on "Placement" for worship as The High Alter Of Absolute Success.
Those are all based on years of personal exposure to the aftermaths of shootings on the job, are all my own opinions, and others are free to form their own.
The "Placement" mantra I see way too often simply isn't realistic.
The head as a unit is not all that easy to hit when everybody's moving, even then a hit to the lower half or a grazing strike may not instantly stop aggression, and the section that will is relatively small.
Heard of WWII Finnish sniper Simo Hayha?
Shot in face by a Soviet rifleman in 1940, lost a good section of his left cheek.
Survived.
Remember Moshe Dayan?
His eye patch was the result of a sniper bullet through the binoculars he was using one day in 1941.
Obviously survived.
The actual triangle that IS a guaranteed instant shutdown is pretty much at the top of the nose between the eyes, and relatively small.
Torso-wise, a CNS/spinal strike can stop the action right now, but again that's a tall & very narrow target.
I see way too much emphasis given to "Placement", and far too many people putting far too much misguided faith in it.
"Don't matter what I shoot, placement'll save me!"
BS.
You can't count on YOU being able to pull it off, you can't count on PLACEMENT being able to pull it off.
FMJ penetration, with the least tissue disruption of any bullet type, is another false god to worship.
In an already marginal caliber, using the least effective bullet in terms of tissue disruption that you possibly can strikes me as counterproductive, to say the very least.
Placement & FMJ penetration are two very commonly misunderstood & misguided theories that way too many people base too much confidence on.
Having said all that, not interested in arguing or defending, I've got my experiences, others have their sources to use in selection & use with a .380.
Denis