By "1st model" I'm assuming you've got the old style Vaquero with the beefy frame. These are of course "Ruger only" loads for the large frame guns, not the newers Vaqs.
Bullets in the 250-265 range will be softer shooting, but still plent of punch for hunting. Use something with a large meplat like WFN, LFN, or a Keith style semi wadcutter. Push them at 1100 or 1200 fps and the bullet will do its part. I like Lil Gun, but there's lots of powders that will do well for your application. 20-21 grains of Lil Gun will put you at about 1200 fps in those bullets. More than enough for any whitetail.
Besides the Hodgdon data,
this Taffin article is a good guide, and there's a load posted on Handloads using a 265 grain WFN and your gun.
21 grains of Lil Gun, 1259 fps. That 265 grain WFN from Cast Performance is a good choice, and
Montana Bullet Works makes nice little 250 grain WFN, among others.
I'd also check out AA#9 (
online data here). Those 17.6 and 17.5 loads for the 255 and 265 cast bullets are only running about 20,000 psi, and should be pleasant shooting.