I am comfortable enough if only revolvers are within reach, though I am more comfortable if a shotgun or appropriate carbine is available. For that matter, I am comfortable enough with only revolvers if out and about town.
My wife has large-enough hands to prefer K- and L- frame revolvers, and her favored revolver is a 7-shot L-frame snubbie. Some have mentioned 8-shot revolvers; well, gentlemen, MY hands are not large enough to manage an N-frame well in DA mode, much less my wife's hands.
There is indeed a solution for the OP: add more SP101 five-guns! If the OP's wife has chosen the SP101, then that is HER preferred platform. The SP101 grip may well be perfect for her hands; why argue with success?
Jim Cirillo, dubbed Cirillo the Great by no less than Col. Jeff Cooper, believed in multiple
revolvers for the street, and the greatest non-military gunfighter of the last half of the 20th Century probably knows a thing or two about the subject. Rather than argue with success, I have also adopted the multiple-revolver strategy for some of my carry, though my current duty pistol, the SIG P229, also gets into the mix.
FWIW, my wife is a forensic investigator for one of the nation's largest counties, by population, and investigates more death scenes than most people in the USA, and she is comfortable with revolvers for SD/HD.
