Mine ran like crap out of the box, Ruger was happy to take it back and fix it. But, I read that the Valquartson extractor would cure the stove pipes so I decided to spend the 12 bucks. The extractor did the trick. Ammo is the limiting factor with good stuff it runs nonstop. The cheap ammo has plenty of duds. The ammo that runs poorly in my 22/45 wont run at all in my buddies pistols.
So, I can highly recommend it you are willing to change the extractor. Now many 22/45 owners will report the same results with the factory extractor. I also installed the valquaetson sear, trigger, and mag disconnect bushing. What a major difference!!! Not even the same gun... I have only one bitch about this pistol and it can not be fixed. The magazines seat like crap so sometimes after a few shots the mag drops enough to stop feeding. Now if I am cautious when sticking the mag in its not a problem, but it seems that when my buddies shoot it, it happens often.
To throw some mud into the water, the buckmark has a much better trigger out of the box compared to the Ruger , but I have not seen my friends shoot enough to speak about reliability. With good ammo it ran great. Now that said the Ruger with the mods has a much better trigger. Most guys who try it say its the best trigger they have ever shot.
Lastly, the Rugers are one of the few 22s that can be dry fired without damage.
Sorry for the long winded answer!!