Prosser, you keep looking to find a way to get a tighter cylinder bore. Yet from all I've read the last thing a revolver should have is chamber mouths that are sized at or less than the barrel bore. The idea is that the bullets are to be kept a bit large and guided to the forcing cone where the forcing cone squeezes them down and eases them into the rifling. This way the rifling gets a good bite on the side of the bullet. This both guides the bullet better and at the same time seals the bore more effectively by blocking any blowby gasses.
So with the slightly oversize barrel bore the last thing it would appear to want is a "tight" chamber mouth. You want to keep things matched up size wise so they work together. The one size sets the needs of the other.
The one or two places where there may be room for improvement if you really must is at the forcing cone and at the muzzle crown. Apparently all else being equal a longer forcing cone angle eases the bullet into the rifling with less deformation. And of course a match grade muzzle crown lapped onto a truly accurately cut muzzle will ensure that the front end of the barrel is doing its job the best it can. Do the Ruger's need this work? That would depend on what the angles and crown are like from the factory. The results of most of us would suggest that overall the gun is already pretty darn good and that it shoots better than most of us can hold the darn thing.
There is also much testing to be done both with various factory ammo as well as then redoing the same tests with accuraized ammo I'd be willing to bet that at some point you find a combo which suits your stanadards.
Besides, from what you suggested above about your shooting ability you won't see any difference in most of the ammo, accurrized or not, unless you borrow a Ransom Rest to do your ammo testing.
Speaking of Ransom Rest shooting I did a quick google on "ruger single six ransom rest" and came up with a couple of interesting links. The first in particular using various ammo types is very interesting in terms of grouping sizes when shooting from a new Single Ten.
http://www.gunblast.com/Ruger-SingleTen.htm
Nothing else came up but I did find a few more items when I googled for ".22lr ransom rest".
This one showing the results from a Marvel .22LR conversion kit for a 1911 shows that the Single Ten groupings may well need a bit of help after all. Although other references to the Marvel kit suggest that it's a well done item which allows shooting a 1911 to the highest of match standards. So comparing it to a Single Six or Single Ten may not be all that fair.
http://www.marvelprecision.com/target.php
The first post on this page from the Smith&Wesson forums doesn't have any targets but it does claim that the fellow remembers a K22 shooting consistently at less than the size of a quarter at 50 yards. Darn good if it's true and supportive of the "less than one inch" for the Marvel kit.
http://smith-wessonforum.com/s-w-revolvers-1961-1980/215401-accuracy-k-22-a.html
Fourth post says that this guy's Model 17 shoots about 2 inches from a RR at 50.
http://www.handloadersbench.com/forum34/16777.html
Another RR test without targets but with group sizes given. Check post #2. It further suggests that the targets in the Marvel link are truly "match grade" since they guarantee less than one inch at 50 yards.
There's other links but I've read and posted enough of them to tell myself that the Single Six isn't any worse than a lot of other options out there. However the SS, as well as a number of other well respected guns, are not of the highest match grade standard.
So where does this leave you? You wanted the gun to achieve match grade standards for groupings. From all that has been said in this and the other thread to convert an SS into such a gun is not going to be a one step process. It would involve totally rebuilding the gun taking into account a wide variety of factors. In the end such a gun will have cost you many times the cost of what you could buy a Freedom Arms revolver. Or, as much as I hate to say it since this IS the revolver forum, it comes down to if you want match grade performance of around 1/2 inch at 25 yards then you may need to pass on the idea of a single action revolver if you're not willing to pay the going price to have such a gun made for you. Really when it comes down to it a Marvel Unit 1 kit at $450 or so installed on a RIA 1911 frame would provide you with a $1000 match grade .22 pistol which shoots as accurately as one could wish for.
Where's this leave the Single Six you have? Since it's clear that you are not able or willing to spend the money to have such a gun totally rebuilt to optimize it for shooting .22 I'd suggest that "it is what it is" and you just need to come to terms with that. There's no magical single factor that will make this gun suddenly shoot match grade groups.
You're far better off to just try some various ammo with and without the accurizer and to use the accurrizer to "crush" in carefully measured and controlled amounts to determine what works best in that gun. One of the links (can't find it again now) was from a guy who used the accurizer with a dial guage mounted to the press to consistently control the amount of crush given to the bullet. The targets he also displayed showed that it made some amount of difference. So obviously the use of the accurrizer needs some amount of control to it as well.
And if after all that if the SS doesn't meet your standards then there's always the Marvel kit mounted onto a cheap 1911 lower..... or any number of the old Colt or Hi Standard match grade pistols. There's also the well respected S&W Model 41 and the Beretta 87.