The big elephant in the room that nobody mentions is market share of existing firearms and the proven effectiveness of those arms current in use. The 30-06 is without doubt the most common bolt action rifle in America. They don't wear out so you easily encounter 60 year old bolt action 30-06's that are in regular use today as hunting rifles (older ones, too). Decades of being the most common hunting rifle, along with the ubiquitous 270 and then other common rounds like 308, 30-30, .243, 300 mags, and 7mm Mag, you get a market saturated with arms that cover the gamut of needs in North America. A man whose rifle reliably and consistently kills his intended target is likely a satisfied man.
Sure, he could hunt with something marginally more efficient, in a marginally lighter and shorter gun, but why drop another $500 when his own hunting experience will not be improved? In the woods of Mississippi, all the boutique rounds mentioned have vastly reduced value and utility. Our shots are not super long-distance where bullet drop becomes an issue. As a general rule, our shots are under 300 yards, often closer than 100 yards. All the efficiencies in the world become moot. They offer nothing better than the tried-and-true rounds already offer (is 1/2 pound lighter and 1/2 inch shorter really worth the money?) in the real world. The same is true for the woods of Alabama, Louisiana, Tennessee, Arkansas, Georgia, and other places.
So, the man who has a rifle because he loves hunting, not because he is a gun nut, has what reason to discard his ammo and rifle for a new round? And if he discards said rifle and rounds by selling it, the buyer has no reason to discard his new purchase in favor of something with more limited availability but no greater effective performance.
Those legions of owners of traditional, marginally less-efficient rifles buy ammo. They buy vast amounts as a whole. Nobody will stop making 30-06 ammo for decades even if no new rifles show up in 30-06 because of the colossal numbers of chambered rifles out there. And nothing that requires a bullet to be mounted on case containing propellant powder can possibly be introduced that will bake the 30-06 obsolete. Nothing at all that exists on the planet in small arms ammo makes the 30-06 obsolete today. Nothing. Since nothing does (and those who are about to argue the point go look up the definition of obsolete first), the best a round can do is prove it does the same thing as a 30-06 only more efficiently, faster, shorter, what ever. But nothing out today renders any current rounds obsolete. Even 30-30 remains viable and useful (and thus not obsolete) given the effectiveness in wooded areas and the vast number of chambered rifles.
So, in the end, any new cartridge must rob market share from the vast quantities of arms and users already out there. Nothing new that comes out is so much better as to be worth the increased costs associated with them for a tremendous number of hunters. Those hunters buy ammo. They buy ammo for the arms they currently own. Those arms they currently own are still by tremendous numbers in that cadre of traditional or currently common rounds.
Without commanding market share, newly-introduced rounds have very little chance of going anywhere once the buzz wears off. Check out the .45 GAP.