I've owned one since the stainless versions were released, and I have a friend that bought one of the earliest blued models, so I've had a chance to shoot them since they were first released. Rather than try to repeat everything I've previously written in answer to this question, though, if you don't mind I thought I'd post some links to other threads where this subject was discussed. While you'll read things I've written, you can also read feedback from others in these threads ...
http://www.smith-wessonforum.com/ubb/Forum12/HTML/001088.html
http://www.thefiringline.com/forums/showthread.php?threadid=140317&highlight=CS45+cs45
http://www.smith-wessonforum.com/ubb/Forum12/HTML/000883.html
http://www.smith-wessonforum.com/ubb/Forum12/HTML/000825.html
http://www.pistolsmith.com/viewtopic.php?t=9963&highlight=cs45+cs45
Aide from a couple of the very early issues regarding the overly tight barrel tab/breech face tolerances possibly present in some of the earliest pistols that left the factory, and the early magazines where the secondary indentations apparently weren't exactly positioned opposite each other on some magazines ... these have generally been reported to be great little .45's ...
Anytime a manufacturer makes a very small, large caliber pistol there's always the potential for short slide cycling and reduced slide mass/increased slide velocity issues to pop up ... especially in the hands of folks with "marginal" grip strength & "stability" tendencies ... S&W seems to have created a subcompact .45 that's very reliable in this regard, however ...
While the grip is "chunky", mainly due to the decreased grip height, and the rubber grip designed to cushion the sharp recoil of the lightweight pistol making it seem a little fat in the "girth" ... the front-to-back dimension isn't uncomfortable for a reasonable range of shooters. It's more comfortable, to my hand, than the similar dimension of the Glock G36, which really feels like a 2X4 without any of the cushioning.
The heavy DA trigger is necessitated by the shortest hammer spring used in a S&W TDA pistol, which is due to the shortened grip height.
If the CS45 doesn't fit your hand as well as you'd prefer, though, take a look at the 457S or the 4513TSW. They're compact, versus subcompact, but they aren't really that much larger ... 3.75" barrels versus 3.25" for the CS45 ... and might fit your hand much better, while still being reasonable sized for lawful CCW use, if that's a concern. Both the 457 & 4513 platforms are even more comfortable when it comes to perceived recoil, as well ... although that's all a very subjective thing ...