I've had a S&W 2" Model 64 (the stainless steel version of the M10) and a few Detective Specials. The Colts feel noticably smaller and lighter and the Colt action has a feel of precision to it that the S&W does not.
They have similar accuracy - as far as I can tell from a gun with 2" fixed sights. S&W has a larger grip frame, but many aftermarket grips give many choices for both guns.
The S&W design is probably more durable (it would last 2-3 lifetimes, vs Colt only lasting 1-2 without a tune up). I would also think the S&W would be more friendly to beefier loads. Smith & Wessons are also easier to work on, easier to find a knowledgeable Gunsmith and easier to find parts. Their Customer Service is also great, but they may not work on older guns any more. I have no experience with Colt Customer Service.
S&W still makes plenty of revolvers based on the same design, while I think you can only get the original Colt action guns from their Custom Shop. This means competant Colt gunsmiths will continue to get harder to find. It also probably means old Colts will continue to rise in value as they get scarcer.
It's a tough call on which is "better". If the added weight and size of the M64 is too much, you might want to consider their J frame revolvers - which are even smaller than the DS. But than you have to worry about 5 shots or 6.....
Did I mention - even wth all the negatives I pointed out about the Colts - I still have 2 DSs and an SFVI. I sold the M64, but I do have a Model 60 with a 3" barrel.