I was thinking about babying it since it was so old.
You sure know how to hurt the OLD Fuff, who was buying guns when the one you have was made during the early 1960's. I (sniff) could use some babying...
Plus-P ammunition comes in many flavors, but the very most hotest won't blow up your revolver. What it can do though, if it's used extensively as a steady diet, is cause an undesireable condition called cylinder end shake.
Cylinder end shake is back and forth movement of the cylinder (as opposed to rotational movement). It comes about when the heavy cylinder batters the end of the yoke barrel (the part the cylinder rotates on).
I know because I have corrected the condition in endless numbers of revolvers (in particular S&W K-frame .38's) that spent most of their lives in law enforcement service where they sometimes saw an unusual amount of Plus-P ammunition.
Plus-P ammunition, more often then not, comes with someone's super-tactical bullet that's jacketed, and costs more then ordinary cast lead ones. If you feel that you must have the latest in such loads (I don't) then by all means carry them. I'm not so sure they will make a meaningful difference, but if they make you feel better go ahead. On the other hand if the cost savings will allow you to practice more... well that could make a difference.
You now have one of the best service revolvers ever made. All you have to do is learn how to best use it.