I just bought a Nikon Buckmaster Side Focus 6-18X40 with BDC reticle. BTW I recommend the BDC reticle. It only costs about $10-$15 more. It is super clear and at 18 power you can see the mites on a deer's back nearly. I put it on my new Stevens Model 200 .223 Remington. But I have a Remington 700 ADL Synthetic in 22-250 that wears a Leupold VX-1 4-12X40. I"m thinking about swapping those scopes. I think it would make more sense to have the more powerful scope on the .22-250. They are both OK Scopes and both are plenty clear for what I do with them.
The 4.5-14x40 would be good on your 22-250 I think. I have a Leupold Side Focus 4.5-14X56MM 30mm Tube VX-3L ordered to put on a build that is in progress. I took one of my Yugo Mauser barreled actions to my gun smith in Refugio Texas and he's bending the bolt, drilliing and tapping the receiver for scope mounts, installing a Timney Sporter trigger and a Model 70 Win. style 3 position swing safety and a Shilen 27 inch SS .257 Cal. barrel and reaming the chamber to .257 Roberts Ackly Improved. The bluing on the receiver is still excellent and I'm going to DuraCoat the Barrel in satin black. I will bed it in a Boyd's Pepper Laminant Classic Stock. This will be my third build as I have an old Obendorf 98 large ring Mauser action with a 26 inch ER Shaw heavy sporter Chrome Moly 7mm barrel reamed to 280 Remington with a Timney Trigger and two position safety. It also has a Leupold VX -1 3-9X40 Scope in Leupold Redfield style mounts on it. I have worked up two loads for this, one is a 140 grain Nosler Ballistic Tip over 57 grains IMR 4831 and the other is a 150 grain Nosler Ballistic Tip over 56 grains IMR 4831 that goes through my Chrony at about 2990-3010 FPS MV.
I also have a Howa 1500 action with a Krieger heavy Sporter SS 25.5 inch .250 caliber barrel with the chamber reamed to .250 Savage. It sits in the original Howa stock and is bedded in and the original Howa trigger has been reworked by my gunsmith and lightened down to about 1.5-2 pounds. It has a Leupold 3-9X40 Vari-X II scope (Which is really the same as the newer VX-1s) on it in silver to match the SS barrel. It is throated out to accept 117 and 120 grain bullets without crowding the powder capacity. I worked up a load of a Hornady 117 Grain Spire Point bullet over 39.5 grains of IMR 4831 at 2700 FPS. But I'm still working that load up. I forsee it getting to 40.5-41 grains of powder before it tops out and close if not over 2800 FPS, which is a very potent load for the little .250 Savage.
Though I love these builds, I still love my 22-250 more than ever. It's hot, it's accurate, there's hardly any recoil, and it will kill Texas white tail deer bang flop DRT. I think it will be even better with the 6-18x40 Buckmaster scope on it.