Well first of all, I think you mistyped the max load from the Hornady manual, I'm looking at my copy of he 9th edition Hornady manual and I see a max load of 44.9gr.
Of course your next point will probably be that regardless, why is there such a difference between two manuals and, as I've told a lot of other people that have asked the same question, you have to pay attention to the details.
Each manual will specify how the load was developed and rarely will they use the same components or weapons to develop the powder charge recommendations. I have the 48th edition of Lyman's manual and it specifies that they used a Remington case, a Remington 9 1/2 primer, and a 24" universal receiver while Hornady says that they used a Hornady case, a Federal 210 primer, and a 22" barreled Winchester 70 model rifle. The different cases will have different volumes which will produce different pressures using the same amount of powder. The different primers will produce different burn patterns which will result in different pressures also. The longer barreled universal receiver used by Lyman will handle higher pressures and it will produce faster velocities than the shorter barreled model 70 used by Hornady. Take note also that Lyman shows that they get 2632 fps with 42.5gr of Varget (in the longer barrel) and Hornady indicates that they get 2600 fps with 42.6gr of Varget.
Checking for estimated max pressures using my QuickLoad internal ballistic software, Hornady uses a lighter max powder charge than Lyman for whatever reason, maybe they don't like the pressure curve that Varget has for the .308 Win cartridge but both manuals show a max powder charge weight that produces max pressure that is well under the SAAMI maximum recommendation. Since the bullets are made by Hornady, maybe Hornady knows something about the bullet's construction that Lyman doesn't, maybe Hornady doesn't think that the bullet is capable of being as accurate with powder charge weights heavier than 44.9gr of Varget. Maybe, since Hornady used a Winchester Model 70 rifle to develop their load information, they figured that 44.9gr of Varget produced the max pressure that they felt was reasonable for that rifle's action.
Regardless, I'll use the bullet manufacturers recommendation before I would someone else's. Oh, and by the way, try around 42.5gr of Varget with that bullet.