Some of the advice I'm seeing here is a bit peculiar.
If you're doing Kentucky windage the old rule is that you'll want to aim lower for both uphill and downhill shots. What you need to remember here is that your bullet is impacted by gravity only for its horizontal distance to the target (the portion parallel to the surface of the earth). The slant distance that you're measuring is actually the long edge of the triangle (the hypotenuse). You need to mathematically figure out the distance of the horizontal component of your shot, which is what you'll be aiming for.
If you have a calculator and a couple of basic tools this isn't hard to work out. Here's how it goes: Let's assume that you have a rangefinder and an inclinometer for this shot, because those tools would be close to essential to work out the math easily.
You range your target, and find that it is 450 yards away. You check your inclinometer and find that your target is at a 23 degree down angle from you.
Take the COSINE (COS button) of your 23 degree angle, and you'll get 0.920. Multiply 0.920 X 400 yards, and you'll get 368. Now aim as if you're shooting at a target that is 368 yards away. You'll find that the effect is more pronounced as your angle increases.
As for the A-hole in Vegas, I've already heard members of the media refer to this guy as an expert marksman with sniper-like skill. That's total BS. The guy fired thousands of rounds into a tightly packed crowd of people. He used the fish in the barrel approach, and nothing I said above applies to anything that this psychopath did that night.