Hotshotshoting:
We now have pistols that have been proven, with the proper combination of bullet and powder charge to kill as effectively as 375 H&H rifles. When I first started shooting, this was NOT the case, with hotrodded 45 Colt being the heaviest bullet weight, and .44 magnum being the light fast, with solids, ala Lee Jurras loads.
MOST of the time, the effect of full metal jacket rifle calibers is a one shot stop. However, they are still dependent on wound mechanics: they need to create a large permanent wound channel, and, a large temporary cavity. Put bluntly, a FMJ can penetrate straight through, not hit anything hard, and just keep on going. The frontal section doesn't allow much of a temporary cavity to form, and, the permanent channel can be small enough, and, not hitting anything vital, so it doesn't stop anything.
However, despite the Hague, the bullet guys get around it by picking light bullets, likely to fragment, creating a large temporary cavity, and, multiple wounding fragments, and, when .308 bullets tumble, they create havoc, as do .50's. Soft points are a whole nother game.
That said, we now have .500 Maximum Linebaugh, the .475 Linebaugh, that can equal the ballistics of this 12 gauge shotgun slug, and actually exceed it, if you want to:
with devastating results. They accomplish this with bullet expansion, causing a huge permanent wound channel, and, a very large temporary cavity, both long, because the bullet maintains speed through the target, and, wide, due to pretty high hitting velocity, combined with wide frontal area, that quickly expands.
This combination gives you a larger effective disruptive target radius around the impact point of a bullet then the service calibers:
These pistols have the same ballistics as the old 50-110 rifles. They were never accused of not being effective one shot stoppers...
My point is starting with 10mm, there are handgun cartridges that far exceed the effectiveness of the service caliber rounds, and, due to a combination of bullet design, and velocity are far more effective then the service calibers, and, equal rifle ballistics in some cases, that have a long history of being very effective.