Mine is muzzle up, leaning against the bedpost. I can reach over with either hand and have it 'at ready' in seconds. I have actually practiced and since it is between the bed and nightstand muzzle down takes longer to fish it out. When I brab it by the muzzle, it is basically a jerk/throw in the direction of the door and my hands go naturally to where they should.
When it was muzzle down I tended to want to 'steer' the muzzle out and THEN swing... it just took longer.