I'd stay away from a 10/22 unless you're going to be modding it.
Agreed. My brother has a .22, and for the life of me I can not get used to the sights. If you are willing to drop $100-200 on it in parts, scope, etc, then it might be the right thing for you. However, for about $330 you can get a cz 452, which in my opinion is a far better gun. I know, I know, its not an autoloader, but those have the slickest bolts and nicest lines of any .22 I've ever seen! Last week at the Newington Gun Exchange I saw a few, including a full stock, which I was drooling over for about 30 minutes, but elected to save my money. Frankly I'd rather spend the money on ammo and parts for my current guns than buy new ones, at least until I have more money. I say, save the money, wait a few months, then buy a CZ, but thats just me.
P.S., I have a henry, which is a nice gun too, but if I were buying again, it would be a CZ, only because the henry has "iffy" sights from the factory.