If you want brute strength and don't want to pop for a Freedom arms...Ruger Blackhawk and Super Blackhawk. If you want fixed sights, the original, "big" Vaqueros are equally strong, but currently out of print. You can occasionally find one in good shape, but be prepared to pay a premium.
Somebody please start a rumor that Ruger will reissue the large-frame Vaquero. Maybe if there's enough clamor for it, Ruger will respond.
If you want something a bit smaller and lighter in .45 Colt...lately, I've been gettin' cozy with a pair of New Vaqueros, and can't say enough good about'em. Even with fairly large hands, I like the slim grips.
They're accurate...easy to carry...print to point of aim at 25 yards with a 250-grain cast bullet and the long-accepted and well-established favorite load of 9 grains of Unique...and my chronograph insists that the velocity at 15 feet is an impressive 900+ fps from the 4 and 5/8ths barrels. From a 5.5-inch tube, a thousand fps wouldn't be a stretch.
No, they're not recommended for use with the "Ruger Only" load data in the manuals, though I have a suspicion that they're stronger than many believe them to be...but they're not Blackhawks. There's no sense in beating up a fine revolver and shortening its useful service life for an extra 200 fps. For anything short of large or dangerous animals...if you can't git'r'done with a 250 at 950 fps..you probably can't do any better with the same bullet at 1150. If you need more, go with a Super Blackhawk and enjoy all the buck and roar that the .44 Magnum will provide.