The .44 S&W Special is at home in an N-frame...
But I have had no ejection problems with .45 Long Colt in N frame S&W's. They work fine in that revolver design. But the fact is, the .44 S&W Special was designed for the N-frame, and vice versa...
Both were introduced in 1909 as a matched pair, and they work together beautifully, just like the .38 S&W Special and the K frame (1899) and the .45 ACP and the 1911 (1910). There is a trend for guns and cartridges designed around each other to just fit right unlike later cartridges adapted to that frame.
Now, the argument that the .45LC works as well in the N frame is valid; the two cartridges are very similar in their SAAMI loadings of pressure and projectile weight. I do not find a major difference between .44 Special, .45LC, and .45 acp when shooting them from an N-frame S&W. All three rounds are very similar in pressure, projectile weight, diameter, and velocity. Within the loading range of each caliber, they overlap so much as to be indistinguishable in most cases if the shooter is blindfolded.
So I do not accept the fact that one is "vastly" superior in a large double action revolver at all - that's nonsense and could only be based on a lack of experience with the different calibers.
1) DA S&W large frame revolver in .45 Long Colt, shoots just as sweet as a .44 or .45acp: