Personally, at one time I had a 357, 44, and 45ACP to feed. This was not a bad deal, but changing the primer system on the Dillon became a mitigating factor for change. The 357 went down the road. Then over time I swapped N frames 629 for a 625 (Model of 1988). This was a good thing, as now there was only 45ACP's to load and keep track of. Well, both ate the same thing. The Gold Cup and 625 shared the same meal. This was the end of a logistical nightmare. Only one primer and one powder and one bullet. Pretty much a no-brainer! And, I have stuck to that same line of thinking. Till earlier this spring when a 22.250 turned into a 357. Well, the 357 was fun to plink with, but well there was the primer deal, again. Well, I know that some may think that is a cop out, but for ease of things it is just down right practica. The only real changes are the 1911 variant turned into a 220. That sort of evolved into a 4506; it in turn was turned into a 1911, again. Well, then as time wore on, the 1911 turned into a USP. So, I have 625's and USP's. They do not share the same meal, but the same bullet style. The 625 eats LRN's, and the USP's get plated RN's.
Not to much to compromise on. A few twists to the powder charge bar and the Dillon is set to make breakfast, lunch, and supper.
For me, I do not need any thing overly powerful, such as a 44 or anything stronger then the 45ACP.