In my opinion, the ruger mark II and all variants...(I have a 22/45) are like glocks in the sense that they are indestructible and amazingly reliable...
I have had my ruger 22 for a year and a half...Just got around to cleaning it earlier this week....
I had shot maybe 1500 rounds through it, without one single malfunction, failure to fire, failure to eject, etc....
Never even oiled the thing. They are definitely the "workhorse" of plinking.
As far as ergonimics and "pointability" go, they arent great...I can point shoot much easier with my Steyr M9.. they are also heavy, but that is ok (bull models)....it will make your everyday carry gun feel very light in comparison.
If you dont already have a 22 plinker, ruger is definitely the way to go...they are cheap, reliable, and accurate. And not to mention crazy cheap to shoot....Every time my friends and I go out shooting, we alway end up putting more rounds through our rugers than anything else....they are just fun, and you dont feel your wallet throb every time you pull the trigger.
One more thing...I love the mag design....there is nothing easier to load than a ruger 22 magazine.....just pull down the pin, and start dropping them in.
Also, they are infinitely customizable....There are a couple companies that make upgrade parts for almost every part of the gun....If I had the money, I would get mine silenced, just for the "gee wiz" factor...and so I can scrap my earplugs while using it....Apparently they sound like pellet guns with a good silencer.
So if you are looking for a good plinking gun (or a good "mob cleaner" gun) then you cant go wrong with the rugers.