There is no risk of jamming when you flip a safety off or draw a firearm from a holster. There is a risk of jamming when you load the first round off of a fresh magazine. Might be slight but it's still there.
The first thing I want if I'm suddenly presented with the problem of someone trying to kill me, isn't another problem. I want a solution to the original problem.
If your "nightstand gun" doesn't have a safety that you are happy with, keep it in a holster. I do, even on the guns I own with safeties. Any condition one gun in my house that's ready for self defense is chambered and ready to fire; as soon as you pull it from the holster. The exception is a 6-shot 38 special I keep in the kitchen. It has a strong enough double action trigger pull I'm not really concerned with keeping it in a holster.
But the nightstand gun, desk gun, couch gun, and other guns (5 level house, have to keep one on each level...) .. they're ready to fire once you draw them from the holster.