Obviously whatever gun(s) and ammunition have to be reliable. If all four, including their ammo, are highly reliable, then there is another important consideration: Would it/they be kept loaded or unloaded?
If kept loaded, the Marlin and/or the revolver. The best shot in the world may need more than one shot, as from what I have read about carefully document incidents of this sort, sometimes more than one shot is needed by the defender. If so, that next shot is virtually guaranteed needed immediately! For that matter more than two shots may be required. The fastest man in the world would not be able to reliably reload under such conditions if things go worse than most people choose to expect. There actually have been a few instances where an attacker was not stopped by a 12 gauge slug to the chest. Rare? Ultra rare! Not what I'd expect either, but I'd still rather have multiple .22LRs over a single 12 or .410 round. Of course there may be more than one attacker and even stopping the first does not guarantee the others will quit.
Yet there is a much more common likelihood: The defender may miss or only get a marginal hit and this does not stop the attack. You think you can't miss at such short range? Please consider the attacker is moving and not always as you might expect; the light will be bad; you did not expect this specifically (unlike getting ready to fire on the range); you may have been sleepy and now you're probably shaking, especially since you don't know exactly what to expect.
OTOH, if the gun(s) is/are to be kept unloaded, then the breakopens are the fastest to load.
Oh, someone touched on this previously, but I'll expand. If the defender is just going to wait for the attacker to come through a locked door or otherwise past a certain point, then a long gun is better, space preventing an immediate grab by the attacker(s). If the defender has to go through the house, handguns are better.
