While those articles are interesting, I know what exits and wound tracts I've personally examined, and if we get past the opinion of 350 lb deer being bullet proof, I know what a slurry of 6mm pills will do at many various impact velocities on quite a few different shot angles. We can include .22 cf on good sized muleys too if you like.
I never meant to imply that I thought 350 lb mule deer are bullet proof. First, we don't have many, if any, 350 lb deer here unless they are called elk. What I will state outright is that I have rifles in the safe that will do a better job than my 243 with less effort. My carbine has a pretty stout barrel on it and it weighs in at 8 lbs with optic. For that weight, I can shoot 100 grain bullets at 2700 or so, but I do have a fake hip. My Tikka T3 Hunter weighs in at just under 7 lbs with optic and shoots 130 grain Accubonds at 2800 fps. If I wanted to shoot 22 I could use my 22-250 with a 50 TTSX which works well for me at my altitude, but again my Tikka weighs a 1/2 lb less than my Cooper and shoots harder farther so what do you think I grab when the nuts need cutting?
The only advantage my 243 carbine has is that it fits in my Wrangler really really well, but so does my 30-30 Marlin which I dare say is a better deer/elk slayer than my 243 as long as I keep it under 150 yards. Really the deal is that I just really like that carbine. The fact that mine is a 243 is secondary. It could be a 6mm Rem or a 308 for all I care. I don't have a great love affair with the 243 cartridge, but I don't dislike it. It's the least potent of all the 308 based cartridges, but it is still fine.