My family was in the Jewelry business when I was growing up, and handguns were a common thing in our family. My brother one afternoon placed a 1911 in his front slacks pocket (he is a big boy, 6'3" 280 pounds) while taking a break during the busy Christmas season, and sat down. The pistol was cocked and had a round chambered. He shifted his weight and something triggered it. Who knows, keys, whatever. The round entered his upper thigh, and exited just above his knee cap. He recovered with no serious permanant damage.
I say this just to demonstrate that I have witnessed the danger of IMPROPER pocket carry first hand. With all that said, I carry a Glock 26 with a round in the chamber, in a DeSantis Nemisis pocket holster almost daily (dress requirements for work and the weather often do not permit anything else). I never, and I mean never put anything in that pocket except the holstered pistol.
Now, I will readily admit it is not quick to deploy, but it is still better than not having it at all. When dress permits (most weekends) I do carry with a proper holster and belt.