Harder? No.So, even if this had been mainly about a burglary (which it isn't) then, by your responses, it would be harder to find and take your guns if they were all in one place than if they were spread around the house?
Wouldn't matter much.
Before you leap to the gunsafe response, realize they can still be in safes hidden around the house.
Consider the size and weight of one big safe,,,,