Step#1 - make your home less attractive to break-ins than your neighbors' homes.
Step#2 - realize that owning a firearm will not stop a burglarly while you aren't home,
but may add another gun to the black market. If you are likely to be burgled, you really should secure/disable any firearms you own. Some will tell you that it isn't ethically your problem if someone steals your gun - and to a degree, I agree - but you certainly don't want an effective tool to get into criminal hands.
Step#3 - gun shopping! (see below)
sohcgt2 said:
Find a local public range that offers rental guns and go shoot a variety of guns from various MFG. and of various calibers. If you have a buddy who shoots ask them to go with you and see if you can shoot their guns. I know if a non shooting friend of mine asked me I would gladly take them to the range and let them shoot my guns if they wanted to buy the ammo.
Good advice there. Rent and shoot, borrow and shoot - what works for you will become apparent after a few sessions, allowing you to narrow down the possibilities. On a side note, I've even provided the ammo and safety gear for people new to handguns. If you do have someone ask you to purchase ammunition for a range session, be sure you know EXACTLY what they want you to pick up - take an empty box to match with the important parts highlighted if you have to. I'm not implying that you are incapable of purchasing ammunition on your own, but I can attest to the ease of getting the wrong thing when you are new to the ammunition designations.
Blackbeard said:
I strongly encourage you to take a basic handgun safety course and learn the dynamics of shooting, and get a feel for handling your pistol. Bring the wife too, and anyone else who may ever handle the weapon with your permission.
Good advice there also, you may want to just take the CCW course as well, if available in your area.
Thinking of CCW, home defense guns are not necessarily CCW guns - each requires a different set of compromises. You can go as large as you like for home defense, but it has to be comfortable for all possible home defenders to operate. A CCW, on the other hand, needs to be concealable, but you get to have YOUR top ergonomic choice. While some people do manage to get one handgun to do both jobs (actually, 3 jobs if you count cheap range time), don't get hung up on
"the last gun you will ever need" when looking for a first pistol.