I burn a lot of 2400, it meters well and gives great performance . unique is ok but like everyone else said, you'll be pushing its limits to get what 2400 can do without much fuss. I do have a 357 carbine but I can't comment on the use of 4227 in it, haven't tried but I've got some and don't care for it from even a 6" revolver. My carbine doesn't shoot most cast bullets very well though- it'll do well with the 180 wfn bullets but the bolt is tough to close if seated at the crimp groove .
I mostly load a 158 grain xtp over h110 for my carbine and that's an excellent combo that I can get very good accuracy with and it's reasonably powerful. Stinks having specific cartridges intended just for the carbine but my revolvers do fine with that load too if I need to have ammo compatibility. Otherwise it's just 158 swc over 14 grains of 2400 (older manuals list that charge but some modern manuals list max at 13.5 grains, I've used 14 grains for years and it's fine in my guns) I load those by the hundreds , easily my most fired load and has been for a while.