Pros:
* Very powerful round passing the power of the .357 Magnum full house loads by a decent margin through the same length barrel; yet at the same time: can be bought (or made) very light, around .40 S&W power loads. Thus very versatile. Has lighter recoil than a hot .357 Magnum revolver, and can be reloaded (imo) much faster and easier, with obviously much superior capacity, as well.
* Good for having only one gun if you live in or near the woods, yet go into the city (or town) often from there; keep one mag with FMJ for bear defense, and the other mag full of JHP for two-legged BG defense.
* Higher capacity than a .45 ACP (2 rounds more in a 10mm Glock 20, as compared to a .45 ACP Glock 21; Glock 20 15+1, Glock 21 13+1), yet superior power and versatility compared to the .45 ACP and even .45 Super.
* For a more concealable 10mm pistol, check out the Glock 29.
Cons:
* Hard to find [good] 10mm ammo in local areas, and thus forced to order online to get the good "hot" stuff (
www.doubletapammo.com), and cheaper practice 10mm rounds (
www.georgia-arms.com).
* More expensive to buy as compared to the popular calibers, but not by THAT much... if you know where to look (check links above).
* A bit more recoil with the hotter rounds as compared to the 9mm, .40 S&W, and .45 ACP. But not too bad, as long as you practice... like you'd do with any of them.
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For me, living in the woods, and working in and near the woods, but having to travel into the city and towns afterward, I find having a 10mm Glock 29 on me as my CCW a good compromise, for bear and human criminal defense.