A critical factor is the use of a GOOD BULLET.
By that, I mean a Nosler partition, Barnes TSX, and similar-"premium" bullets.
Bullets such as these offer excellent penetration and weight retention, both of which are highly desirable for shooting moose.
In my decades of living and hunting in the far North, I never lost a moose or caribou. Mostly my Remington .30-06 with 200-grain Partitions served as my moose rifle, but a few were taken with the TSX in later years. The TSX actually retains MORE weight than the Partition, percentage-wise, but the older Nosler design is perfectly adequate.
Put a GOOD bullet in a vital spot with an adequate cartridge, and that moose is yours...