Back in 1908 Colt introduced a series of updated hand ejector revolvers. These included the Police Positive, Police Positive Special (of which the Detective Special is a variant) and the Army Special (which became the Offical Police and the grandparent of the Python).
In one form or another they remained in production until the 1990's, and it should be obvious that if they were prone to go out of time or were fragile they would have been discontinued in short order, or after World War Two at least. As it was they became a mainstay of U.S. law enforcement and were purchased in considerable numbers by our military establishment. Eventually they were discontinued because they required expert hand fitting during final assembly, and this method of manufacture could not continue in an era of much higher labor costs.
Shooting these guns does not cause them to go out of time. What does is abuse - especially flipping the cylinder in and out - which shouldn't be done with any make of hand ejector revolver. Also they're are some late production guns that were never fitted correctly because the company's management decided to fire the more experienced assemblers to save money and replace them with less experienced (and less expensive) new ones. Union strikes allso took a toll.
However those that are good are very, very good - and offer both reliability and exceptional accuracy. If the one you get is slightly out of time send it in to the factory for a tune-up, and thereafter if it isn't abused it will last for a long, long time. I expect that when I'm long gone my 50's Detective Special will still be in perfect time, and lock up like a bank vault door.
In closing I must say that it doesn't have any polymer parts, but I'll try to live with that...